By getting genetic testing done earlier, you can have more targeted treatment options available to you

Genetic testing is suggested when you’re first diagnosed with prostate cancer, especially if you have1,2:

  • A family history of prostate cancer
  • ⁨⁨Ashkenazi Jewish ancestry
  • A family or personal history of breast cancer
  • High-risk or advanced prostate cancer, no matter your family history
If you have any of these, it’s important to talk to your doctor about early genetic testing to help find the best treatment options for you.

Types of genetic testing1,3

Germline testing is a type of genetic testing that can determine whether you’ve inherited a DNA mutation, like BRCA, that is known to increase the risk for certain cancers.

This test is usually performed when you are first diagnosed, particularly if you have a family history that increases your risk.

  • Performed through a cheek swab, saliva sample, or blood sample
  • If you are BRCA positive, your family members should also consider genetic testing2

Somatic testing, which is genetic testing of the tumor, may be performed if the initial germline test is negative to help confirm the presence of specific DNA mutations such as BRCA.

Somatic testing of the tumor typically occurs if your cancer has progressed or spread to other parts of the body.

  • This test is performed through a biopsy of the tumor

Both types of genetic testing determine whether or not a BRCA mutation is present. The presence of this mutation helps your doctor decide which treatments can best fit your needs

Healthcare provider in scrubs showing tablet to older couple during medical consultation

Somatic testing, which is genetic testing of the tumor, may be performed if the initial germline test is negative to help confirm the presence of specific DNA mutations such as BRCA.

Somatic testing of the tumor typically occurs if your cancer has progressed or spread to other parts of the body.

  • This test is performed through a biopsy of the tumor
Both types of genetic testing determine whether or not a BRCA mutation is present. The presence of this mutation helps your doctor decide which treatments can best fit your needs
A negative test result doesn’t always mean your cancer has no BRCA mutation. If this test is negative, your doctor may recommend checking a tumor sample for confirmation, especially upon progression4

Your healthcare professionals and genetic counselors are available to help you understand your results

Because RUBRACA specifically treats prostate cancer with a BRCA mutation, genetic testing is required before patients can start treatment.3 Your doctor will help you with the testing process and understanding the results.4

Understand why RUBRACA may be the right treatment for you

Learn More

BRCA, BReast CAncer gene.

REFERENCES: 1. Tuffaha H, Edmunds K, Fairbairn D, et al. Clinical guidelines for genetic testing in prostate cancer: a scoping review. Prostate Cancer Prostatic Dis. 2024;27(3):594-603. 2. Xu J, Lu J, Gielzak M, et al. Germline testing for prostate cancer patients: evidence-based evaluation of genes recommended by NCCN guidelines. Prostate. 2025;85(11):1087-1095. 3. BRCA gene changes: cancer risk and genetic testing. National Cancer Institute. https://www.cancer.gov/about-cancer/causes-prevention/genetics/brca-fact-sheet 4. RUBRACA (rucaparib). Prescribing Information. pharmaand GmbH. 2025.
Tap for safety information

IMPORTANT SAFETY INFORMATION

What is RUBRACA® (rucaparib) used for?

RUBRACA tablets are a prescription medicine used in adults for:

  • The treatment of castration-resistant prostate cancer (prostate cancer that no longer responds to medical or surgical treatment that lowers testosterone):
    • That has spread to other parts of the body (metastatic), and
    • Has a certain type of inherited (germline) or acquired (somatic) abnormal BRCA gene, and you have been treated with certain medicines for your cancer.
  • Your healthcare provider will perform a test to make sure RUBRACA is right for you.

It is not known if RUBRACA is safe and effective in children.

What Warnings should you know about RUBRACA?

RUBRACA tablets may cause serious side effects including: Bone marrow problems called Myelodysplastic Syndrome (MDS) or a type of cancer of the blood called Acute Myeloid Leukemia (AML). Some people who have cancer and who have received previous treatment with chemotherapy or certain other medicines for their cancer have developed MDS or AML during or after treatment with RUBRACA. MDS or AML may lead to death. If you develop MDS or AML, your healthcare provider will stop treatment with RUBRACA. Symptoms may include weakness, weight loss, fever, frequent infections, blood in urine or stool, shortness of breath, feeling very tired, bruising or bleeding more easily. Symptoms of low blood cell counts are common during treatment with RUBRACA, but can be a sign of serious problems, including MDS or AML.

Before you take RUBRACA, tell your healthcare provider about all of your medical conditions, including if you are a male with a female partner who is pregnant or able to become pregnant, effective birth control should be used during treatment and for 3 months after the last dose of RUBRACA. Do not donate sperm during use and for 3 months after the last dose of RUBRACA.

What other important information should I know about RUBRACA?

Your healthcare provider will do blood tests before and every month during treatment with RUBRACA to monitor your blood cell counts. Weekly blood tests will be performed if you have low blood cell counts for a long time. Your healthcare provider may stop treatment with RUBRACA until your blood cell counts improve.

Avoid spending time in sunlight while on RUBRACA since your skin may become more sensitive to the sun and may sunburn more easily. You should wear a hat and clothes that cover your skin and use sunscreen to help protect against sunburn if you have to be in the sunlight.

What are the side effects of RUBRACA?

The most common side effects of RUBRACA in people with prostate cancer include: tiredness or weakness, muscle and joint pain, nausea, decrease in hemoglobin (anemia), decreased appetite, changes in liver and kidney function tests, constipation, diarrhea, vomiting, low blood cell counts, shortness of breath, swelling in your legs and feet, dizziness, decreased weight, stomach area (abdominal) pain, changes in how food tastes, rash, tingling sensation and numbness, cough, headache, urinary tract infection, bleeding, photosensitivity reaction.

These are not all the possible side effects of RUBRACA. Call your healthcare provider for medical advice about side effects.

What other medications might interact with RUBRACA?

RUBRACA can increase the amounts of other medications you may be taking, which can increase the risk of side effects. Tell your healthcare provider about all your medical conditions and all medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to pharma& at 1-800-506-8501.

  • This information is not comprehensive.
    • How to get more information:
      • Talk to your health care provider or pharmacist.
      • Visit www.rubracaprostate.com to obtain the FDA-approved product labeling.

Please see full Prescribing Information for RUBRACA.

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